Latest Tech News
New High-Speed 3D Microscope Could Make Biopsies a Thing of the Past
MediSCAPE, a high-speed 3D microscope developed by Columbia Engineers, can see cellular details in living tissue in real time to guide surgeries, speed up tissue analysis, and improve treatments.
A Columbia Engineering team has developed technology that could replace traditional biopsies and histology with real-time imaging in the living body. Described in a new article published today (March 28, 2022) in Nature Biomedical EngineeringMediSCAPE is a high-speed 3D microscope capable of capturing images of tissue structures that could help surgeons navigate tumors and their borders without having to remove tissue and wait for pathological results.
In many medical procedures, particularly cancer surgery and checkups, it is common for doctors to take a biopsy and cut out small pieces of tissue for a closer look with a microscope. “The way biopsy samples are processed hasn’t changed in 100 years, they are excised, fixed, embedded, sliced, stained with dyes, positioned on a slide and viewed by a pathologist with a simple microscope. Because of this, it can be days before you get any news about your diagnosis after a biopsy,” says Elizabeth Hillman, professor of biomedical engineering and radiology at the[{” attribute=””>Columbia University and senior author of the study.
Hillman’s group dreamed of a bold alternative, wondering whether they could capture images of the tissue while it is still within the body. “Such a technology could give a doctor real-time feedback about what type of tissue they are looking at without the long wait,” she explains. “This instant answer would let them make informed decisions about how best to cut out a tumor and ensure there is none left behind.”
Another major benefit of the approach is that cutting tissue out, just to figure out what it is, is a hard decision for doctors, especially for precious tissues such as the brain, spinal cord, nerves, the eye, and areas of the face. This means that doctors can miss important areas of disease. “Because we can image the living tissue, without cutting it out, we hope that MediSCAPE will make those decisions a thing of the past,” says Hillman.
Although some microscopes for surgical guidance are already available, they only give doctors an image of a small, single 2D plane, making it difficult to quickly survey larger areas of tissue and interpret results. These microscopes also generally require a fluorescent dye to be injected into the patient, which takes time and can limit their use for certain patients.
Over the past decade, Hillman, who is also Herbert and Florence Irving Professor at Columbia’s Zuckerman Mind Brain Behavior Institute, has been developing new kinds of microscopes for neuroscience research that can capture very fast 3D images of living samples like tiny worms, fish, and flies to see how neurons throughout their brains and bodies fire when they move. The team decided to test whether their technology, termed SCAPE (for Swept Confocally Aligned Planar Excitation microscopy) could see anything useful in tissues from other parts of the body.
“One of the first tissues we looked at was fresh mouse kidney, and we were stunned to see gorgeous structures that looked a lot like what you get with standard histology,” says Kripa Patel, a recent PhD graduate from the Hillman lab and lead author of the study. “Most importantly, we didn’t add any dyes to the mouse –everything we saw was natural fluorescence in the tissue that is usually too weak to see. Our microscope is so efficient that we could see these weak signals well, even though we were also imaging whole 3D volumes at speeds fast enough to rove around in real time, scanning different areas of the tissue as if we were holding a flashlight.”
As she “roved around,” Patel could even stitch together the acquired volumes and turn the data into large 3D representations of the tissue that a pathologist could examine as if it were a full box of histology slides.
“This was something I didn’t expect — that I could actually look at structures in 3D from different angles,” says collaborator Dr. Shana Coley, a renal pathologist at Columbia University Medical Center who collaborated closely on the study. “We found many examples where we would not have been able to identify a structure from a 2D section on a histology slide, but in 3D we could clearly see its shape. In renal pathology in particular, where we routinely work with very limited amounts of tissue, the more information we can derive from the sample, the better for delivering more effective patient care.”
The team demonstrated the power of MediSCAPE for a wide range of applications, from analysis of pancreatic cancer in a mouse, to Coley’s interest in non-destructive, rapid evaluation of human transplant organs such as kidneys. Coley helped the team get fresh samples from human kidneys to prove that MediSCAPE could see telltale signs of kidney disease that matched well to conventional histology images.
The team also realized that by imaging tissues while they are alive in the body, they could get even more information than from lifeless excised biopsies. They found that they could actually visualize blood flow through tissues, and see the cellular-level effects of ischemia and reperfusion (cutting off the blood supply to the kidney and then letting it flow back in).
“Understanding whether tissues are staying healthy and getting good blood supply during surgical procedures is really important,” says Hillman. “We also realized that if we don’t have to remove (and kill) tissues to look at them, we can find many more uses for MediSCAPE, even to answer simple questions such as ‘what tissue is this?’ or to navigate around precious nerves. Both of these applications are really important for robotic and laparoscopic surgeries where surgeons are more limited in their ability to identify and interact with tissues directly.”
A critical final step for the team was to reduce the large format of the standard SCAPE microscopes in Hillman’s lab to something that would fit into an operating room and could be used by a surgeon in the human body. Post-doctoral fellow Wenxuan Liang worked with the team to develop a smaller version of the system with a better form factor, and a sterile imaging cap. PhD candidate Malte Casper helped to acquire the team’s first demonstration of MediSCAPE in a living human, collecting images of a range of tissues in and around the mouth. These results included rapidly imaging while a volunteer literally licked the end of the imaging probe, producing detailed 3D views of the papillae of the tongue.
Eager to take this technology to the next level with a larger clinical trial, the team is currently working on commercialization and FDA approval. Hillman adds, “We are just so amazed to see what MediSCAPE reveals every time we use it on a new tissue, and especially that we barely ever even needed to add dyes or stains to see structures that pathologists can recognize.”
Hillman and her team hopes that MediSCAPE will make standard histology a thing of the past, putting the power of real-time histology and decision making into the surgeon’s hands.
Reference: “High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue” 28 March 2022, Nature Biomedical Engineering.
DOI: 10.1038/s41551-022-00849-7
Latest Tech News
MIT Uses AI To Discover Hidden Magnetic Properties in Multi-Layered Electronic Material
![Hidden magnetic properties in multilayer electronic material](http://minorupdate.in/wp-content/uploads/2022/04/MIT-Uses-AI-To-Discover-Hidden-Magnetic-Properties-in-Multi-Layered.jpg)
MIT researchers discovered hidden magnetic properties in multilayer electronic material by analyzing polarized neutrons with neural networks. Credit: Ella Maru Studio
A[{” attribute=””>MIT team incorporates AI to facilitate the detection of an intriguing materials phenomenon that can lead to electronics without energy dissipation.
Superconductors have long been considered the principal approach for realizing electronics without resistivity. In the past decade, a new family of quantum materials, “topological materials,” has offered an alternative but promising means for achieving electronics without energy dissipation (or loss). Compared to superconductors, topological materials provide a few advantages, such as robustness against disturbances. To attain the dissipationless electronic states, one key route is the so-called “magnetic proximity effect,” which occurs when magnetism penetrates slightly into the surface of a topological material. However, observing the proximity effect has been challenging.
The problem, according to Zhantao Chen, a mechanical engineering PhD student at MIT, “is that the signal people are looking for that would indicate the presence of this effect is usually too weak to detect conclusively with traditional methods.” That’s why a team of scientists — based at MIT, Pennsylvania State University, and the National Institute of Standards and Technology — decided to try a nontraditional approach, which ended up yielding surprisingly good results.
What lies beneath, and between, the layers
For the past few years, researchers have relied on a technique known as polarized neutron reflectometry (PNR) to probe the depth-dependent magnetic structure of multilayered materials, as well as to look for phenomena such as the magnetic proximity effect. In PNR, two polarized neutron beams with opposing spins are reflected from the sample and collected on a detector. “If the neutron encounters a magnetic flux, such as that found inside a magnetic material, which has the opposite orientation, it will change its spin state, resulting in different signals measured from the spin up and spin down neutron beams,” explains Nina Andrejevic, PhD in materials science and engineering. As a result, the proximity effect can be detected if a thin layer of a normally nonmagnetic material — placed immediately adjacent to a magnetic material — is shown to become magnetized.
But the effect is very subtle, extending only about 1 nanometer in depth, and ambiguities and challenges can arise when it comes to interpreting experimental results. “By bringing machine learning into our methodology, we hoped to get a clearer picture of what’s going on,” notes Mingda Li, the Norman C. Rasmussen Career Development Professor in the Department of Nuclear Science and Engineering who headed the research team. That hope was indeed borne out, and the team’s findings were published on March 17, 2022, in a paper in Applied Physics Review.
The researchers investigated a topological insulator — a material that is electrically insulating in its interior but can conduct electric current on the surface. They chose to focus on a layered materials system comprising the topological insulator bismuth selenide (Bi2Se3) interfaced with the ferromagnetic insulator europium sulfide (EuS). Bi2Se3 is, by itself, a nonmagnetic material, so the magnetic EuS layer dominates the difference between the signals measured by the two polarized neutron beams. However, with the help of machine learning, the researchers were able to identify and quantify another contribution to the PNR signal — the magnetization induced in the Bi2Se3 at the interface with the adjoining EuS layer. “Machine learning methods are highly effective in eliciting underlying patterns from complex data, making it possible to discern subtle effects like that of proximity magnetism in the PNR measurement,” Andrejevic says.
When the PNR signal is first fed to the machine learning model, it is highly complex. The model is able to simplify this signal so that the proximity effect is amplified and thus becomes more conspicuous. Using this pared-down representation of the PNR signal, the model can then quantify the induced magnetization — indicating whether or not the magnetic proximity effect is observed — along with other attributes of the materials system, such as the thickness, density, and roughness of the constituent layers.
Better seeing through AI
“We’ve reduced the ambiguity that arose in previous analyses, thanks to the doubling in the resolution achieved using the machine learning-assisted approach,” say Leon Fan and Henry Heiberger, undergraduate researchers participating in this study. What that means is that they could discern materials properties at length scales of 0.5 nm, half of the typical spatial extent of proximity effect. That’s analogous to looking at writing on a blackboard from 20 feet away and not being able to make out any of the words. But if you could cut that distance in half, you might be able to read the whole thing.
The data analysis process can also be sped up significantly through a reliance on machine learning. “In the old days, you could spend weeks fiddling with all the parameters until you can get the simulated curve to fit the experimental curve,” Li says. “It can take many tries because the same [PNR] Signal could correspond to different combinations of parameters.”
“The neural network gives you an instant answer,” Chen adds. “There is no more guesswork. No more trial and error.” For this reason, the framework has been installed in some reflectometry beamlines to support the analysis of broader material types.
Some outside observers have praised the new study — it’s the first to assess the effectiveness of machine learning in identifying the proximity effect and among the first machine-learning-based packages to be used for PNR data analysis. “The work of Andrejevic et al. provides an alternative way to capture fine detail in PNR data and shows how higher resolution can be consistently achieved,” said Kang L. Wang, Distinguished Professor and Raytheon Professor of Electrical Engineering at the University of California, Los Angeles.
“This is really exciting progress,” commented Chris Leighton, Distinguished McKnight University Professor at the University of Minnesota. “Their new approach to machine learning could not only significantly speed up this process, but also extract even more material information from the available data.”
The MIT-led group is already considering expanding the scope of their investigation. “The magnetic proximity effect is not the only weak effect that interests us,” says Andrejevic. “The machine learning framework we developed can be easily applied to different types of problems, such as the superconducting proximity effect, which is of great interest in research[{” attribute=””>quantum computing.”
Reference: “Elucidating proximity magnetism through polarized neutron reflectometry and machine learning” by Nina Andrejevic, Zhantao Chen, Thanh Nguyen, Leon Fan, Henry Heiberger, Ling-Jie Zhou, Yi-Fan Zhao, Cui-Zu Chang, Alexander Grutter and Mingda Li, 17 March 2022, Applied Physics Review.
DOI: 10.1063/5.0078814
This research was funded by the U.S. Department of Energy Office of Science’s Neutron Scattering Program.
Latest Tech News
Could We Make Cars Out of Petroleum Residue?
Through
A new method of making carbon fiber could turn refinery by-products into high-quality, ultra-lightweight structural materials for cars, planes and spacecraft.
As the world struggles to improve the efficiency of cars and other vehicles to reduce greenhouse gas emissions and increase the range of electric vehicles, the search is on for ever lighter materials that are strong enough to be used in car bodies.
Lightweight carbon fiber materials, similar to the material used in some tennis racquets and bicycles, combine exceptional strength with low weight, but were more expensive to manufacture than comparable steel or aluminum structural members. Well, researchers at[{” attribute=””>MIT and elsewhere have come up with a way of making these lightweight fibers out of an ultracheap feedstock: the heavy, gloppy waste material left over from the refining of petroleum, material that refineries today supply for low-value applications such as asphalt, or eventually treat as waste.
Not only is the new carbon fiber cheap to make, but it offers advantages over the traditional carbon fiber materials because it can have compressional strength, meaning it could be used for load-bearing applications. The new process is described on March 18, 2022m in the journal Science Advances, in a paper by graduate student Asmita Jana, research scientist Nicola Ferralis, professor Jeffrey Grossman, and five others at MIT, Western Research Institute in Wyoming, and Oak Ridge National Laboratory in Tennessee.
![Circle of Carbon Fibers](http://minorupdate.in/wp-content/uploads/2022/04/1648886046_449_Could-We-Make-Cars-Out-of-Petroleum-Residue.jpg)
A circle of carbon fibers which have a diameter of about 10 micrometers. Credit: Nicola Ferralis
The research began about four years ago in response to a request from the Department of Energy, which was seeking ways to make cars more efficient and reduce fuel consumption by lowering their overall weight. “If you look at the same model car now, compared to 30 years ago, it’s significantly heavier,” Ferralis says. “The weight of cars has increased more than 15 percent within the same category.”
A heavier car requires a bigger engine, stronger brakes, and so on, so the reducing the weight of the body or other components has a ripple effect that produces additional weight savings. The DOE is pushing for the development of lightweight structural materials that match the safety of today’s conventional steel panels but also can be made cheaply enough to potentially replace steel altogether in standard vehicles.
Composites made from carbon fibers are not a new idea, but so far in the automotive world they have only been used in a few very expensive models. The new research aims to turn that around by providing a low-cost starting material and relatively simple processing methods.
![Human Hair and Carbon Fiber](http://minorupdate.in/wp-content/uploads/2022/04/1648886046_127_Could-We-Make-Cars-Out-of-Petroleum-Residue.jpg)
A human hair and carbon fiber, with a clear ruler on the bottom half of the image. The human hair, pictured in a vertical orientation, is thicker (about 60 micrometers) than the carbon fiber behind it. Credit: Nicola Ferralis
Carbon fibers of the quality needed for automotive use cost at least $10 to $12 per pound currently, Ferralis says, and “can be way more,” up to hundreds of dollars a pound for specialized application like spacecraft components. That compares to about 75 cents a pound for steel, or $2 for aluminum, though these prices fluctuate widely, and the materials often rely on foreign sources. At those prices, he says, making a pickup truck out of carbon fiber instead of steel would roughly double the cost.
These fibers are typically made from polymers (such as polyacrilonitrile) derived from petroleum, but use a costly intermediate step of polymerizing the carbon compounds. The cost of the polymer can account for more than 60 percent of the total cost of the final fiber, Ferralis says. Instead of using a refined and processed petroleum product to start with, the team’s new approach uses what is essentially the dregs left after the refining process, a material known as petroleum pitch. “It’s what we sometimes call the bottom of the barrel,” Ferralis says.
“Pitch is incredibly messy,” he says. It’s a hodgepodge of mixed heavy hydrocarbons, and “that’s actually what makes it beautiful in a way, because there’s so much chemistry that can be exploited. That makes it a fascinating material to start with.”
It’s useless for combustion; although it can burn, it’s too dirty a fuel be practical, and this is especially true with tightening environmental regulations. “There’s so much of it,” he says, “the inherent value of these products is very low, so then it is often landfilled.” An alternative source of pitch, which the team also tested, is coal pitch, a similar material that is a byproduct of coking coal, used for example for steel production. That process yields about 80 percent coke and 20 percent coal pitch, “which is basically a waste,” he says.
Working in collaboration with researchers at Oak Ridge National Laboratory, who had the expertise in manufacturing carbon fibers under a variety of conditions, from lab scale all the way up to pilot-plant scale, the team set about finding ways to predict the performance in order to guide the choice of conditions for those fabrication experiments.
“The process that you need to actually make a carbon fiber [from pitch] is actually extremely small, both in terms of energy requirements and in terms of the actual processing that you need to do,” says Ferralis.
Jana explains that pitch “consists of this heterogeneous group of molecules where you would expect the properties to change dramatically as you change shape or size,” whereas an industrial material must have very consistent properties.
By carefully modeling how bonds form and crosslink between individual molecules, Jana was able to develop a way to predict how a given set of processing conditions would affect the resulting fiber properties. “We were able to reproduce the results so amazingly[{” attribute=””>accuracy,” she says, “to the point where companies could take those graphs and be able to predict” characteristics such as density and elastic modulus of the fibers.
The work produced results showing by adjusting the starting conditions, carbon fibers could be made that were not only strong in tension, as most such fibers are, but also strong in compression, meaning they could potentially be used in load-bearing applications. This opens up entirely new possibilities for the usefulness of these materials, they say.
DOE’s call was for projects to bring the cost of lightweight materials down below $5 a pound, but the MIT team estimates that their method can to do better than that, reaching something like $3 a pound, though they haven’t yet done a detailed economic analysis.
“The new route we’re developing is not just a cost effect,” Ferralis says. “It might open up new applications, and it doesn’t have to be vehicles.” Part of the complication of making conventional fiber composites is that the fibers have to be made into a cloth and laid out in precise, detailed patterns. The reason for that, he says, “is to compensate for the lack of compressive strength.” It’s a matter of engineering to overcome the deficiencies of the material, he says, but with the new process all that extra complexity would not be needed.
Reference: “Atoms to fibers: Identifying novel processing methods in the synthesis of pitch-based carbon fibers” by Asmita Jana, Taishan Zhu, Yanming Wang, Jeramie J. Adams, Logan T. Kearney, Amit K. Naskar, Jeffrey C. Grossman and Nicola Ferralis, 18 March 2022, Science Advances.
DOI: 10.1126/sciadv.abn1905
The research team included Taishan Zhu and Yanming Wang at MIT, Jeramie Adams at Western Reserve University, and Logan Kearney and Amit Naskar at Oak Ridge National Laboratory. The work was supported by the U.S. Department of Energy.
Latest Tech News
Tiny Magnets Could Hold the Secret to Miniaturizable Quantum Computers
![On-chip quantum circuit](http://minorupdate.in/wp-content/uploads/2022/04/Tiny-Magnets-Could-Hold-the-Secret-to-Miniaturizable-Quantum-Computers.jpg)
Photo Credit: Image by Ellen Weiss/Argonne National Laboratory
Magnetic interactions could point to quantum devices.
From MRI machines to computer hard drive storage, magnetism has played a role in crucial discoveries reshaping our society. In the new area of[{” attribute=””>quantum computing, magnetic interactions could play a role in relaying quantum information.
In new research from the U.S. Department of Energy’s (DOE) Argonne National Laboratory, scientists have achieved efficient quantum coupling between two distant magnetic devices, which can host a certain type of magnetic excitations called magnons. These excitations happen when an electric current generates a magnetic field. Coupling allows magnons to exchange energy and information. This kind of coupling may be useful for creating new quantum information technology devices.
“Remote coupling of magnons is the first step, or almost a prerequisite, for doing quantum work with magnetic systems,” said Argonne senior scientist Valentine Novosad, an author of the study. “We show the ability for these magnons to communicate instantly with each other at a distance.”
This instant communication does not require sending a message between magnons limited by the speed of light. It is analogous to what physicists call quantum entanglement.
![Remote Magnon Magnon Coupling Circuit Schematic](http://minorupdate.in/wp-content/uploads/2022/04/Tiny-Magnets-Could-Hold-the-Secret-to-Miniaturizable-Quantum-Computers.png)
Schematic of the remote magnon-magnon coupling circuit. Two single-crystal YIG spheres are embedded to the NbN coplanar superconducting resonator circuit, where microwave photon mediates coherent magnon-magnon interaction. Credit: Image by Yi Li/Argonne National Laboratory
Following on from a 2019 study, the researchers sought to create a system that would allow magnetic excitations to talk to one another at a distance in a superconducting circuit. This would allow the magnons to potentially form the basis of a type of quantum computer. For the basic underpinnings of a viable quantum computer, researchers need the particles to be coupled and stay coupled for a long time.
In order to achieve a strong coupling effect, researchers have built a superconducting circuit and used two small yttrium iron garnet (YIG) magnetic spheres embedded on the circuit. This material, which supports magnonic excitations, ensures efficient and low-loss coupling for the magnetic spheres.
The two spheres are both magnetically coupled to a shared superconducting resonator in the circuit, which acts like a telephone line to create strong coupling between the two spheres even when they are almost a centimeter away from each other – 30 times the distance of their diameters.
“This is a significant achievement,” said Argonne materials scientist Yi Li, lead author of the study. “Similar effects can also be observed between magnons and superconducting resonators, but this time we did it between two magnon resonators without direct interaction. The coupling comes from indirect interaction between the two spheres and the shared superconducting resonator.”
One additional improvement over the 2019 study involved the longer coherence of the magnons in the magnetic resonator. “If you speak in a cave, you may hear an echo,” said Novosad. “The longer that echo lasts, the longer the coherence.”
“Before, we definitely saw a relationship between magnons and a superconducting resonator, but in this study their coherence times are much longer because of the use of the spheres, which is why we can see evidence of separated magnons talking to each other,” Li added.
According to Li, because the magnetic spins are highly concentrated in the device, the study could point to miniaturizable quantum devices. “It’s possible that tiny magnets could hold the secret to new quantum computers,” he said.
The magnonic devices were fabricated at Argonne’s Center for Nanoscale Materials, a DOE Office of Science user facility.
A paper based on the study, “Coherent coupling of two remote magnonic resonators mediated by superconducting circuits,” was published in the January 24 issue of Physical Review Letters.
Reference: “Coherent Coupling of Two Remote Magnonic Resonators Mediated by Superconducting Circuits” by Yi Li, Volodymyr G. Yefremenko, Marharyta Lisovenko, Cody Trevillian, Tomas Polakovic, Thomas W. Cecil, Peter S. Barry, John Pearson, Ralu Divan, Vasyl Tyberkevych, Clarence L. Chang, Ulrich Welp, Wai-Kwong Kwok and Valentine Novosad, 24 January 2022, Physical Review Letters.
DOI: 10.1103/PhysRevLett.128.047701
Other authors of the study include Argonne’s Volodymyr Yefremenko, Marharyta Lisovenko, Tomas Polakovic, Thomas Cecil, Pete Barry, John Pearson, Ralu Divan, Clarence Chang, Ulrich Welp and Wai-Kwong Kwok. Cody Trevillian and Vasyl Tyberkevych of Oakland University in Michigan also contributed to the research.
The research was funded by DOE’s Office of Science (Office of Basic Energy Sciences).
MmzHrrdb
May 8, 2022 at 8:39 pm
1
MmzHrrdb
May 8, 2022 at 8:39 pm
1